ea0070aep22 | Adrenal and Cardiovascular Endocrinology | ECE2020
Gao Xin
, Yamazaki Yuto
, Pieroni Jacopo
, Tezuka Yuta
, Omata Kei
, Ono Yoshikiyo
, Morimoto Ryo
, Nakamura Yasuhiro
, Satoh Fumitoshi
, Sasano Hironobu
Introduction: Aging is associated with the pathogenesis of many endocrinological disorders, especially for functioning adrenocortical disorders. In addition, mitochondria DNA abnormalities have been reported to be correlated with aging through ROS which eventually resulted in cell senescence. We previously reported that cortisol-producing adenomas (CPA) expressed more abundant cell senescent markers including p16 and p21, compared to other hormone-producing adenomas. However, ...